Electrophysiological effects of dronedarone(SR 33589), aa noniodinated amiodarone derivative in the canine heart: comparison with amiodarone

摘要

The electrophysiological effects of dronedarone, a new nonionidated analogue of amiodarone were studied after chronic and acute administration in dog Purkinje fibres, papillary muscle and isolated ventricular myocytes, and compared with those of amiodarone by applying conventional microelectrode and patch-clamp techniques. Chronic treatment with dronedarone(2×25 mg~-1 kg~-1 day p.o. for 4 weeks), unlike chronic administration of amiodarone(50 mg~-1 kg~-1 day p.o. for 4 weeks), did not lengthen significantly the QTc interval of the electrocardiogram or the action potential duration(APD)in papillary muscle.