Polymorphisms in ion channel genes: emerging roles in pain

摘要

Why does one soldier, after sustaining a missile wound in thenradial nerve on the battlefield, experience incapacitating neuro-npathic pain, while another, with a similar injury, complains ofnmotor and sensory deficits in the absence of pain? Why is onenpatient with diabetic neuropathy disabled with neuropathic pain,nwhile another patient with diabetic neuropathy of apparently simi-nlar severity experiences numbness or paraesthesias that are notnpainful? Pain is a complex phenomenon, mediated by transductivenprocesses in the periphery, conduction to the spinal cord via