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Influence of mechanical stress on cell viability

机译:机械应力对细胞活力的影响

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The cartilage is a hydrated connective tissue in joints that withstands and distributes mechanical forces. The chon-drocytes utilize mechanical signals to regulate their metabolic activity through complex biological and biophysical interactions with the extracellular matrix (ECM). The aim of this work was to study the influence of mechanical stress on cells behavior cultured in 3D biosystems (alginate and alginate supplemented with hyaluronate). After mechanical stimulation, cell viability and cell death process were the main studied parameters. Our results indicated that viability and cell cycle progression were inhibited under mechanical stimulation, as far as the extracellular matrix was not yet synthesized. In contrast, on day 21, the mechanical stimulation had positive effect on these parameters.
机译:软骨是关节中的水合结缔组织,可承受和分布机械力。软骨细胞利用机械信号通过与细胞外基质(ECM)进行复杂的生物学和生物物理相互作用来调节其代谢活性。这项工作的目的是研究机械应力对3D生物系统(藻酸盐和藻酸盐补充透明质酸盐)中培养的细胞行为的影响。机械刺激后,细胞活力和细胞死亡过程是主要研究参数。我们的结果表明,只要尚未合成细胞外基质,在机械刺激下就抑制了活力和细胞周期进程。相反,在第21天,机械刺激对这些参数产生了积极影响。

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