A model of higher accuracy for the individual haplotyping problem based on weighted SNP fragments and genotype with errors

摘要

Motivation: In genetic studies of complex diseases, haplotypes provide more information than genotypes. However, haplotyping is much more difficult than genotyping using biological techniques. Therefore effective computational techniques have been in demand. The individual haplotyping problem is the computational problem of inducing a pair of haplotypes from an individual's aligned SNP fragments. Based on various optimal criteria and including different extra information, many models for the problem have been proposed. Higher accuracy of the models has been an important issue in the study of haplotype reconstruction.