DETECT—a Density Estimation Tool for Enzyme ClassificaTion and its application to Plasmodium falciparum

摘要

Motivation: A major challenge in genomics is the accurate annotation of component genes. Enzymes are typically predicted using homology-based search methods, where the membership of a protein to an enzyme family is based on single-sequence comparisons. As such, these methods are often error-prone and lack useful measures of reliability for the prediction.