P(2)BAT: a massive parallel implementation of PBAT for genome-wide association studies in R

摘要

The software tool P(2)BAT provides a massive parallel and user friendly implementation of the PBAT-analysis tools for family-based association tests (FBATs) in large-scale studies, including genome-wide association studies with several thousand subjects. Built on the original PBAT-implementation of the Lange-Van Steen algorithm to bypass the multiple testing problem in family-based association studies, P(2)BAT integrates all PBAT-analysis tools for binary and complex traits into R and makes them accessible through a user-friendly GUI. The genome-wide analysis tools are fully automated and can be ran massively parallel directly through the GUI. P(2)BAT is fully documented and contains graphical output tools for time-to-onset analysis. P(2)BAT also features the ability to test for gene and environment/drug interaction.