Interferon-γ inducible exchanges of 20S proteasome active site subunits: Why?

摘要

When cells are stimulated with the cytokines IFN-γ or TNF-α, the synthesis of three proteasome subunits LMP2(βli) LMP7 (β5i), and MECL-1(β2i) is induced. These subunits replace the three subunits delta (β1), MB1(β5) , and Z(β2), which bear The catalytically active sites of the proteasome, during proteasome neosynthesis.