首页> 外文期刊>Biochimie >Snake postsynaptic neurotoxins: gene structure, phylogeny and applications in research and therapy [Review]
【24h】

Snake postsynaptic neurotoxins: gene structure, phylogeny and applications in research and therapy [Review]

机译:蛇突触后神经毒素:基因结构,系统发育及其在研究和治疗中的应用[综述]

获取原文
获取原文并翻译 | 示例
       

摘要

Snake venoms are complex mixtures of biologically active polypeptides that target a variety of vital physiological functions in mammals. alpha-Neurotoxins, toxins that cause paralysis by binding to the nicotinic receptors at the postsynaptic region of the neuromuscular junction have been widely studied in terms of their structure-function relationships as well as gene structure, organization and expression. In this review, we describe the structure of alpha-neurotoxin genes and discuss their evolutionary relationships. Almost all members of neurotoxins have been found to exhibit a common evolutionary origin. The importance of alpha-neurotoxins in therapy and research has also been discussed to highlight their potential applications especially in the area of drug discovery. (C) 2003 Elsevier SAS. All rights reserved. [References: 107]
机译:蛇毒是针对哺乳动物各种重要生理功能的生物活性多肽的复杂混合物。 α-神经毒素是通过与神经肌肉接头的突触后区域的烟碱样受体结合而引起麻痹的毒素,已从其结构功能关系以及基因结构,组织和表达方面进行了广泛研究。在这篇综述中,我们描述了α-神经毒素基因的结构并讨论了它们的进化关系。已发现几乎所有神经毒素成员都表现出共同的进化起源。还讨论了α-神经毒素在治疗和研究中的重要性,以突出其潜在的应用,尤其是在药物发现领域。 (C)2003 Elsevier SAS。版权所有。 [参考:107]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号