A set of polyclonal and monoclonal antibodies reveals reveals major differences in post-translational modification of the rat NHF1 and vHNF1 homeoproteins

摘要

The related homeodomain-containing transcription factors HNF1 (HNF1α and vHNF1 (HNF1β) recognize common target DNA sequences in the regulatory regions of many genes and are expressed in several parenchymal cell types, predominantly in liver, kidney, intestine and pancreas. HNF1-null mutant mice, with a wild-type vHNF1 gene, develop normally, but die within a few weeks of birth with severe liver and kidney failure.