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Trehalase of Dictyostelium discoideum: inhibition by amino-containing analogs of trehalose and affinity purification

机译:盘基网柄菌的海藻糖酶:海藻糖的含氨基类似物的抑制和亲和纯化

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摘要

The inhibitory effects of three nitrogen containing analogs of trehalose, validamycin A, MDL 25 637 and castanospermine, on Dictyostelium discoideum trehalase were examined. Prior to this study, the effects of glycohydrolase inhibitors on D discoideum trehalase have not been reported. Validamycin A, MDL 25 637 and castanospermine were found to be potent, reversible, competitive inhibitors of D discoideum vegetative trehalase in vitro with IC_50 values of 1*10~-9 M, 2*10~-8 M and 1.25*10~-4 M, respectively.
机译:考察了三种含氮海藻糖类似物,有效霉素A,MDL 25637和粟精胺对盘基网柄菌海藻糖酶的抑制作用。在此研究之前,尚未报道糖水解酶抑制剂对D Discoideum海藻糖酶的作用。已发现Validamycin A,MDL 25637和粟精胺是有效的,可逆的,竞争性的D Discoideum植物性海藻糖酶抑制剂,IC_50值为1 * 10〜-9 M,2 * 10〜-8 M和1.25 * 10〜-分别为4M。

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