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Upregulation of glyceraldehyde-3-phosphate dehydrogenase mRNA in the spleen of tumor-bearing mice

机译:荷瘤小鼠脾脏中3-磷酸甘油醛脱氢酶mRNA的上调

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摘要

The influence of tumor implantation on glyceraldehyde-3-phosphate dehydrogenase(GAPDH)mRNA levels and stability was determined in the spleen of tumor-bearing mice. While GAPDH mRNA levels were not altered in skeletal muscle, kidney and liver from tumor-bearing mice, tumor implantation led to a 5.6-fold increase in the levels of splenic GAPDH mRNA. An enhanced message stability was observed in splenocytes from tumor-bearing animasl, suggestingthe involvement of post-transcriptional mechanisms in the selective GAPDH mRNA accumulation after tumor implantation.
机译:确定了荷瘤小鼠脾脏中肿瘤植入对3-磷酸甘油醛脱氢酶(GAPDH)mRNA水平和稳定性的影响。尽管荷瘤小鼠骨骼肌,肾脏和肝脏中GAPDH mRNA的水平没有改变,但是肿瘤植入导致脾GAPDH mRNA的水平增加了5.6倍。在荷瘤动物的脾细胞中观察到增强的信息稳定性,表明转录后机制参与肿瘤植入后选择性GAPDH mRNA积累。

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