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Amphibian metamorphosis as model for studying the developmental actions of thyroid hormone

机译:两栖动物变态作为研究甲状腺激素发育作用的模型

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摘要

The thyroid hormones L-thyroxine and triiodi-L-thyronine have profound effects on postembryonic development of most vertebrates. Analysis of their action in mammals is vitiated by the exposure of the developing foetus to a number of maternal factors which do not allow one to specifically define the role of thyroid hormone(TH)or that of other hormones and factors that modulate its action. Amphibian metamorphosis is obligatorily dependent on TH which can initiate all the diverse physiological manifestations of this postempbryonic developmental process(morphogenesis, cell death, re-structuring, etc.)in free-living embryos larvae of most anurans.
机译:甲状腺激素L-甲状腺素和三碘-L-甲状腺素对大多数脊椎动物的胚胎后发育具有深远的影响。通过将发育中的胎儿暴露于多种母体因素中来消除对它们在哺乳动物中的作用的分析,这些母体因素无法具体定义甲状腺激素(TH)或其他激素的作用以及调节其作用的因子。两栖动物的变态是强制性地依赖TH的,TH可以在大多数无环果的自生胚胎幼虫中引发这种胚胎后发育过程的所有多种生理表现(形态发生,细胞死亡,重组等)。

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