A New goldfish model to evaluate pharmacokinetic and pharmacodynamic effects of drugs used for moion sichness in different gravity loads

摘要

This paper proposes a new goldfish model to predit pharmacodynamic/pharmacokinetic effects of drugs used to treat motion sickness administered in differing gravity loads. The assumptionof these experiments is that the vestibular system is dominant in producing motion sickness and that the visual system is secondary or of small import in the production of motion sickness.