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Searching for Life on Mars: Selection of Molecular Targets for ESA's Aurora ExoMars Mission

机译:在火星上寻找生命:ESA的Aurora ExoMars任务的分子靶标选择

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The European Space Agency's ExoMars mission will seek evidence of organic compounds of biological and non-biological origin at the martian surface. One of the instruments'in the Pasteur payload may be a Life Marker Chip that utilizes an immunoassay approach to detect specific organic molecules or classes of molecules. Therefore, it is necessary to define and prioritize specific molecular targets for antibody development. Target compounds have been selected to represent meteoritic input, fossil organic matter, extant (living, recently dead) organic matter, and contamination. Once organic molecules are detected on Mars, further information is likely to derive from the detailed distribution of compounds rather than from single molecular identification. This will include concentration gradients beneath the surface and gradients from generic to specific compounds. The choice of biomarkers is informed by terrestrial biology but is wide ranging, and nonterrestrial biology may be evident from unexpected molecular distributions. One of the most important requirements is to sample where irradiation and oxidation are minimized, either by drilling or by using naturally excavated exposures. Analyzing regolith samples will allow for the search of both extant and fossil biomarkers, but sequential extraction would be required to optimize the analysis of each of these in turn.
机译:欧洲航天局的ExoMars任务将寻找火星表面生物和非生物来源有机化合物的证据。巴斯德有效载荷中的一种仪器可能是生命标记芯片,该芯片利用免疫分析方法来检测特定的有机分子或分子类别。因此,有必要为抗体开发定义特定的分子靶标并确定其优先级。选择了目标化合物来代表气象输入,化石有机物,现存(活着的,最近死亡的)有机物和污染。一旦在火星上检测到有机分子,可能会从化合物的详细分布而不是单个分子的鉴定中获得更多信息。这将包括表面下的浓度梯度以及从一般化合物到特定化合物的梯度。生物标记物的选择是由陆地生物学决定的,但范围很广,从意外的分子分布来看,非陆地生物学可能很明显。最重要的要求之一是通过钻孔或使用自然开挖的暴露来使辐照和氧化最小化的样品。分析重石块样品将允许搜索现存和化石生物标志物,但是需要顺序提取以依次优化每个生物标志物的分析。

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