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首页> 外文期刊>Asian Journal of Andrology >Mass screening of prostate cancer in a Chinese population: the relationship between pathological features of prostate cancer and serum prostate specific antigen
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Mass screening of prostate cancer in a Chinese population: the relationship between pathological features of prostate cancer and serum prostate specific antigen

机译:在中国人群中进行前列腺癌的大规模筛查:前列腺癌的病理特征与血清前列腺特异性抗原之间的关系

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摘要

Aim: To investigate the pathological features of the prostate biopsy through mass screening for prostate cancer in a Chinese cohort and their association with serum prostate specific antigen (PSA). Methods: A total of 12 027 Chinese men in Changchun were screened for prostate cancer by means of the serum total prostate specific antigen (tPSA) test (by Elisa assay). Transrectal ultrasound-guided systematic six-sextant biopsies were performed on those whose serum tPSA value was > 4.0 ng/mL and those who had obstructive symptoms (despite their tPSA value) and were subject to subsequent pathological analysis with the aid of the statistic software SPSS 10.0 (SPSS. Inc., Chicago. USA). Results: Of the 12 027 cases, 158 (including 137 patients whose serum tPSA values were > 4.0 ng/mL and 21 patients [serum tPSA < 4. 0 ng/mL] who had obstructive symptoms) undertook prostate biopsy. Of the 158 biopsies, 41 cases of prostatic carcinoma were found (25.9%, 41/158). The moderately differentiated carcinoma and poorly differentiated carcinoma accounted for 61% and 34%, respectively. A significant linear positive correlation between the serum tPSA and the Gleason scores in the 41 cases of prostatic carcinoma (r = 0.312, P < 0.01) was established. A significant linear positive correlation between the serum tPSA value of the 41 prostatic carcinoma and the positive counts of carcinoma in sextant biopsies was established (r = 0.406, P < 0.01), indicating a significant linear relationship between serum tPSA and the size of tumor. Conclusion: This study was the first to conduct mass screening for prostate cancer by testing for serum tPSA values and the first to investigate the pathological features of prostate cancer in a cohort of Chinese men. Our results reveal that the moderately differentiated carcinoma is the most common type of prostate cancer. This study also has shown that the serum tPSA value in prostate cancer is associated with the Gleason score and the size of tumor.
机译:目的:通过大规模筛查中国队列中的前列腺癌及其与血清前列腺特异性抗原(PSA)的关系,来研究前列腺活检的病理特征。方法:通过血清总前列腺特异性抗原(tPSA)测试(Elisa分析),对长春市12027名中国男性进行了前列腺癌筛查。对血清tPSA值> 4.0 ng / mL以及有阻塞性症状(尽管tPSA值高)的患者进行经直肠超声引导的六次系统活检,并借助统计软件SPSS进行后续病理分析10.0(SPSS。Inc.,美国芝加哥)。结果:12027例患者中,有158例(包括血清tPSA值> 4.0 ng / mL的137例患者和21例阻塞性症状[血清tPSA <4. 0 ng / mL]的患者)进行了前列腺穿刺活检。在158例活检中,发现41例前列腺癌(25.9%,41/158)。中分化癌和低分化癌分别占61%和34%。在41例前列腺癌患者中,血清tPSA和Gleason评分之间存在显着的线性正相关(r = 0.312,P <0.01)。建立的41例前列腺癌的血清tPSA值与六分之一活检组织中的癌阳性数之间存在显着的线性正相关(r = 0.406,P <0.01),表明血清tPSA与肿瘤大小之间存在显着的线性关系。结论:该研究是第一个通过检测血清tPSA值进行大规模筛查前列腺癌的方法,也是第一个研究一组中国男性前列腺癌的病理特征的方法。我们的结果表明,中度分化癌是最常见的前列腺癌类型。这项研究还表明,前列腺癌的血清tPSA值与格里森评分和肿瘤大小有关。

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