Substrate Effects On The Analysis Of Biomolecular Layers Using Au~+, Au_3~+ And C_(60)~+ Bombardments

摘要

Effects of platinum silicon, graphite and PET substrates on the secondary ion yield of sub-monolayer and multilayer samples of Cyclosporin A following 20 keV Au~+, Au_3~+and C_(60)~+ impacts have been investigated. The obtained results of sub-monolayer samples show that platinum enhances the yield of the pseudo-molecular ion following Au~+ and Au_3~+ impacts due to the high density of the substrate that enables the energy of the primary ions to be deposited near the surface. C_(60)~+ impacts on sub-monolayer samples are less effective, but there is an enhancement on PET substrates. Impacts of 20 keV Au~+ and Au_3~+ are not very efficient on multilayer samples. 20 keV C_(60)~+ impacts enhance the yields significantly, especially for the relatively high molecular weight [M+H]~+ ion.