Microelectronic sensor for continuous glucose monitoring

摘要

Continuous glucose monitoring is still a challenging task to be accomplished nowadays. Glucose biosensors are normally composed by disposable parts limiting the glucose measurement to one single time. A continuous glucose monitoring device could help diabetes patients and also the development of an artificial pancreas in near future. Thus, two different biosensors for continuous glucose monitoring based on microelectronics technology using an extended gate field-effect transistor device are presented in this work. Glucose oxidase was immobilized on top of fluorine tin oxide substrates by two distinct methods (by chitosan and by glutaraldehyde) and the enzymatic sensor will be shown to work for the continuous glucose monitoring for glucose concentrations corresponding to a healthy human body. Concentration ranges for normal or abnormal levels were both tested.