Porous silicon nanoparticles as sensitizers for ultrasonic hyperthermia

摘要

Aqueous suspensions of porous silicon nanoparticles (NPs) with average size ～100nm and concentration ～ 1 g/L undergo significant heating as compared with pure water under therapeutic ultrasonic (US) irradiation with frequencies of 1-2.5 MHz and intensities of 1-20 W/cm~2. This effect is explained by taking into account the efficient absorption of US energy by NPs. The observed US-induced heating of biodegradable NPs is promising for applications in ultrasonic hyperthermia of tumors.