Interaction between cardiovascular system and respiration

摘要

A set of nonlinear dynamic models for the interactive respiration/cardiovascular mechanism is constructed and analyzed in this work. By employing equivalent electric circuits for heart/blood and lung/air systems, the dynamics of cardiovascular system and respiration cycle are established. In order to verify the validity of the dynamic models, numerical simulations and analysis on heart-lung interactions, including the valvular closure incompetence and pulmonary obstruction, are presented and compared with the empirical reports in literature. The derived dynamics of heart-lung interactions can be realized and examined in the biomechanical and medical engineering fields. In addition, the dynamic models can also be employed for the model-based controller synthesis in medical instrumentations, e.g., the Extracorporeal Membrane Oxygenation (ECMO), to retain the function of blood circulation and/or respiration by artificial intelligence.