首页> 外文期刊>Annals of Occupational Hygiene >Reaerosolization of MS2 Bacteriophage from an N95 Filtering Facepiece Respirator by Simulated Coughing
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Reaerosolization of MS2 Bacteriophage from an N95 Filtering Facepiece Respirator by Simulated Coughing

机译:通过模拟咳嗽从N95过滤式面罩呼吸器中重新雾化MS2噬菌体

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The supply of N95 filtering facepiece respirators (FFRs) may not be adequate to match demand during a pandemic outbreak. One possible strategy to maintain supplies in healthcare settings is to extend FFR use for multiple patient encounters; however, contaminated FFRs may serve as a source for the airborne transmission of virus particles. In this study, reaerosolization of virus particles from contaminated FFRs was examined using bacteriophage MS2 as a surrogate for airborne pathogenic viruses. MS2 was applied to FFRs as droplets or droplet nuclei. A simulated cough (370 l min−1 peak flow) provided reverse airflow through the contaminated FFR. The number and size of the reaerosolized particles were measured using gelatin filters and an Andersen Cascade Impactor (ACI). Two droplet nuclei challenges produced higher percentages of reaerosolized particles (0.21 and 0.08%) than a droplet challenge (0.0001%). Overall, the ACI-determined size distribution of the reaerosolized particles was larger than the characterized loading virus aerosol. This study demonstrates that only a small percentage of viable MS2 viruses was reaerosolized from FFRs by reverse airflow under the conditions evaluated, suggesting that the risks of exposure due to reaerosolization associated with extended use can be considered negligible for most respiratory viruses. However, risk assessments should be updated as new viruses emerge and better workplace exposure data becomes available.
机译:N95过滤式口罩呼吸器(FFR)的供应可能不足以满足大流行期间的需求。在医疗机构中维持供应的一种可能策略是将FFR的使用范围扩展至多次患者接触。但是,受污染的FFR可能是病毒颗粒在空气中传播的来源。在这项研究中,使用噬菌体MS2作为空气传播的病原性病毒的替代品,检查了被污染的FFR中病毒颗粒的再气溶胶化。将MS2作为液滴或液滴核应用于FFR。模拟咳嗽(370 l min -1 峰值流量)通过受污染的FFR提供了反向气流。使用明胶过滤器和Andersen级联撞击器(ACI)测量了再气溶胶化颗粒的数量和大小。与液滴挑战(<0.0001%)相比,两个液滴核挑战产生的再雾化颗粒百分比更高(0.21和0.08%)。总体而言,由ACI确定的再气溶胶化颗粒的粒径分布要大于特征性负载病毒气溶胶。这项研究表明,在评估的条件下,通过逆向气流从FFR中再溶出了少量MS2活病毒,这表明对于大多数呼吸道病毒,由于再溶化与长期使用相关的暴露风险可以忽略不计。但是,应随着新病毒的出现和更好的工作场所暴露数据来更新风险评估。

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