首页> 外文期刊>The Annals of Occupational Hygiene >Effect of Process Parameters Upon the Dopamine and Lipid Peroxidation Activity of Selected MIG Welding Fumes as a Marker of Potential neurotoxicity
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Effect of Process Parameters Upon the Dopamine and Lipid Peroxidation Activity of Selected MIG Welding Fumes as a Marker of Potential neurotoxicity

机译:工艺参数对所选MIG焊接烟气中多巴胺和脂质过氧化活性的影响,作为潜在神经毒性的标志

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摘要

There is growing concern over the neurotoxic effects of chronic occupational exposure to metal fume produced by welding. Elevated iron and manganese levels in the brain have been linked to an increase in lipid peroxidation, dopamine depletion and predisposition to the development of a Parkinson's type condition in advanced cases. Chemical and toxicological analysis of selected welding fumes, generated by model processes, were used in order to evaluate their potential to release solutes that promote oxidation of dopamine and peroxi- dation of brain lipids in cell free assays.
机译:长期职业性接触焊接产生的金属烟雾对神经毒性的影响日益引起人们的关注。大脑中铁和锰水平的升高与脂质过氧化作用的增加,多巴胺的消耗增加以及晚期病例中帕金森氏型病情发展的易感性有关。为了评估在无细胞试验中通过模型过程产生的选定焊接烟雾的化学和毒理学分析,以评估它们释放释放多巴胺氧化和脑脂质过氧化的溶质的潜力。

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