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首页> 外文期刊>Anaesthesia >The influence of propofol or desflurane on postoperative cognitive dysfunction in patients undergoing coronary artery bypass surgery?
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The influence of propofol or desflurane on postoperative cognitive dysfunction in patients undergoing coronary artery bypass surgery?

机译：异丙酚或地氟醚对冠状动脉搭桥手术患者术后认知功能障碍的影响？

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摘要

We investigated the influence of either propofol or desflurane on the incidence of postoperative cognitive dysfunction in a randomised trial of 180 patients undergoing coronary artery bypass surgery. The primary outcome was incidence of postoperative cognitive dysfunction at 3?months, defined as ≥?1 SD deterioration in two or more of 12 neurocognitive tests. Secondary outcomes included early postoperative cognitive dysfunction (between days three and seven), delirium on day one, morbidity and length of hospital stay. Early postoperative cognitive dysfunction was significantly higher with propofol compared with desflurane (56/84 (67.5%) vs 41/83 (49.4%), respectively, p?=?0.018), but this effect was not seen at 3?months (10/87 (11.2%) vs 9/90 (10.0%), respectively. There was no difference in delirium (7/89 (7.9%) vs 12/91 (13.2%), respectively, length of hospital stay (median (IQR [range]) 7 (6-9 [4-15]) vs 6 (5-7 [5-16) days, respectively or other morbidities. Desflurane was associated with reduced early cognitive dysfunction.
机译：我们在一项180例接受冠状动脉搭桥手术的患者的随机试验中研究了异丙酚或地氟醚对术后认知功能障碍发生率的影响。主要结果是术后3个月的认知功能障碍发生率，定义为在12项神经认知测试中的两项或多项中，≥1 SD恶化。次要结果包括术后早期认知功能障碍（第三天至第七天之间），第一天出现ir妄，发病率和住院时间。与地氟醚相比，丙泊酚对术后早期认知功能障碍的发生率显着更高（分别为56/84（67.5％）和41/83（49.4％），p≥0.018），但在3个月时未见这种效果（10）。 / 87（11.2％）vs 9/90（10.0％）。ir妄（7/89（7.9％）vs 12/91（13.2％），住院时间（中位数（IQR））分别无差异[范围]）（分别为7天（6-9 [4-15]）和6天（5-7 [5-16]）或其他疾病。地氟醚与早期认知功能障碍的减轻有关。

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  • 来源
    《Anaesthesia》 |2011年第6期|455-464|共10页
  • 作者

    C. F. Royse; D. T. Andrews; S. N. Newman; J. Stygall; Z. Williams; J. Pang; A. G. Royse;

  • 作者单位

    Professor Anaesthesia and Pain Management Unit Department of Pharmacology University of Melbourne Carlton Victoria;

    and Consultant Anaesthetist Department of Anaesthesia and Pain Management the Royal Melbourne Hospital Australia;

    Consultant Anaesthetist Department of Anaesthesia and Pain Management the Royal Melbourne Hospital and Anaesthesia and Pain Management Unit Department of Pharmacology University of Melbourne Carlton Victoria Australia;

    Professor of Health Psychology and Honorary Consultant Unit of Behavioural Medicine University College London UK and Dean Faculty of Health Sciences City University London UK;

    Senior Research Fellow Unit of Behavioural Medicine University College London UK and Faculty of Health Sciences City University London UK;

    Research Manager;

    Researcher Anaesthesia and Pain Management Unit Department of Pharmacology University of Melbourne Carlton Victoria Australia;

    Associate Professor Department of Surgery University of Melbourne;

    and Cardiothoracic Surgeon Department of Cardiac Surgery The Royal Melbourne Hospital Australia;

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