Surfactant composition in infants and young children with cystic fibrosis

摘要

ew tested the hypothesis that the composition of bronchial surfactant is normal in infants with cystic fibrosis (CF) in the absence of active lung disease but that it is altered by lower respiratory tract infec- tion and inflammation. We examined the total phospholipid (PL), disaturated phospholipid (DSP) surfactant protein-A (SP-A), surfactant protein B (SP-B) and surface activity in bronchoalveolar lav- age fluid from 27 subjects with CF whose mean age was 22.7 (SD 14.5) mo.