Polymorphism in the angiotensin-converting enzyme (ACE) gene and sarcoidosis

摘要

It has recently been shown that an insertion (I)/deletion (D) polymorphism exists in the angiotensin- converting enzyme (ACE) gene, and that this polymorphism affects the serum ACE level. There are three genotypes: DD,DI, and II, with the ACE level highest in DD, intermediate in DI, and lowest in II. In the present investigation of the possible significance of the polymorphism for sarcoidosis, a total Of 207 patients and 314 normal control subjects were examined.