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Leukocytes and decreased left-Ventricular contractility during endotoxemia in rabbits

机译:内毒素血症期间兔白细胞和左室收缩力降低

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ew hypotesized that leukocytes contribute to decreased myocardial contractility following endo- toxin infusion. To test this hypothesis, we administered endotoxin ( 1 mg/kg intravenously) to intact, anesthetized rabbits whose arterial blood perfused two isolated hearts at a constant pressure (75 mm Hg). One heart was perfused with blood passed through a leukocyte filter, whereas the other received unfiltered blood. Contractility of both hearts was measured every 30 min for 6 h, using the slope of the end-systolic pressure-volume relationship (E_max) and the maximum rate of change of intraventricular pressure (dP/dt_max).
机译:有人推测内毒素输注后白细胞会导致心肌收缩力下降。为了验证该假设,我们向内麻醉的兔子施用了内毒素(静脉内1 mg / kg),这些兔子的动脉血在恒定压力(75 mm Hg)下灌注了两个离体的心脏。一颗心脏被灌注通过白细胞过滤器的血液,而另一颗则接受未过滤的血液。使用收缩末期压力-容积关系的斜率(E_max)和心室内压的最大变化率(dP / dt_max),每30分钟测量两次心脏的收缩力,持续6 h。

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