Scar collagen deposition in the airways of allografts of lung transplant recipients

摘要

Collagen subtype deposition has not been studied in the airways of transplanted lungs. As part of re- jection, a series of immunologic insults results in a remodeling of the allograft, In chronic rejection, changes in the airway leading to obliterative bronchiolitis syndrome (OBS) are particularly impor- tant. To better understand the mechanism of OBS occurring in chronic lung rejection, we investi- gated deposition of three fibrillar collagens (type I, III, V) in airway biopsies of lung allografts taken from 10 clinically well lung transplant recipients (wLTR) and eight lung transplant recipients (LTR) with OBS (OBLTR) using an immunoperoxidase method.