Effect of clarithromycin on nasal mucus properties in healthy subjects and in patients with purulent rhinitis

摘要

Erythromycin inhibits mucus glycoconjugate secretion from airway cells in vitro and may increase mu- cus clearance in patients with asthma or diffuse panbronchiolitis. Because mucus hypersecretion is common in purulent rhinitis, we questioned whether clarithromycin would change the properties of nasal mucus from subjects without sinus disease and from patients with acute purulent rhinitis. Nasal secretions were collected before and after nasal methacholine challenge from 10 adults without nasal symptoms and without methacholine from 10 patients with purulent rhinitis.