Effect of short-Term treatment with low-dose inhaled fluticasone propionate on airway inflammation and remodeling in mild asthma: A placebo-controlled study

摘要

In a double-blind, parallel-group study, we examined the effects of short-term treatment with inhaled fluticasone propionate (FP) in a group of 20 nonsmoking asthmatic patients who required only β_2-ag- onists to control their symptoms. We administered FP (250 μg twice daily) or matched placebo for 6 wk. Methacholine challenge was performed before treatment, after 3 wk, and at the end of treat- ment. Each patient underwent bronchoscopy with bronchoalveolar lavage (BAL)and bronchial bi- opsy before and after treatment.