Duloxetine for the management of pain in older adults with knee osteoarthritis: randomised placebo-controlled trial

摘要

Background: pain is the leading symptom of osteoarthritis (OA) and is often chronic in nature, leading to significant morbidity and decreased quality of life. Duloxetine, a selective serotonin norepinephrine reuptake inhibitor has been demonstrated to have a centrally acting analgesic effect.