Propagation Loss-Immune Biocompatible Nanodiamond Refractive Index Sensors

摘要

Propagation loss is a key impeding parameter affecting accuracy, range, and applicability of fluorescent microscopy techniques. In this work, a new nanophotonic platform for propagation loss mitigated fluorescent imaging using lifetime ratiometric measurement is proposed. By applying this methodology to local parameter sensing, a method for high sensitivity local refractive index measurement via lifetime/energy monitoring of fluorescent crystal color centers is numerically demonstrated. As the base of this platform, biocompatible diamond nanodisk structures are investigated that enable sensitive, propagation loss-immune monitoring of refractive index changes both in vitro and in vivo.