Bicontinuous, Thermoresponsive, L_3-Phase Silica Nanocomposites and Their Smart Drug-Delivery Applications

摘要

Silicified L_3-phase gels based on a liposome structure have been prepared, which allow the fabrication of L_3-PNIPAm gels by integration of a thermosensitive polymer with a high degree of continuity in the pore and the network walls. A nanodiffusion mechanism related to the polymer shrinkage and 3D interconnected pores is proposed to explain the remarkable thermosensitive, on-off regulation for IMC delivery by L_3-PNIPAm gels, in which the overall release rate can be sustained over a much longer period of time with a constant release rate. This preliminary study demonstrates the feasibility of designing highly controlled drug-delivery systems, which could be applied to chemotherapy in hard-tissue engineering by using appropriate choices of the porous ceramic matrix (which can include a porous bone material) and the stimuli-sensitive or biodegradable polymers.