Ultrasound-Triggered Smart Drug Release from a Poly(dlmethylsiloxaee)-Mesoporous Silica Composite

摘要

At present, most drug-delivery devices have release rales that are either constant or decay with time. However, there are a number of clinical situations where such an approach may not be sufficient. These include the delivery of insulin for patients with diabetes mellitus, antiarrhythmics for patients with heart rhythm disorders, gastric acid inhibitors for ulcer control, nitrates for patients with angina pectoris, as well as selective (3-blockade, birth control, general hormone replacement and immunization drugs, and cancer chemotherapy. It is highly desirable that drug-delivery patterns are optimized to a pulsatile fashion in which the molecules are naturally released from the body.The on/off or pulsatile control of drug release is especially important for diabetic patients requiring higher doses of insulin after meals.