Reactive Microcontact Printing on Block Copolymer Films: Exploiting Chemistry in Microcontacts for Sub-micrometer Patterning of Biomolecules

摘要

Patterned biofunctional interfacial architectures are currently at the focal point of sensor and cell biology research. For a wide range of possible applications in the life sciences, in particular, the investigation of controlled cell-surface interactions, (bio)chemical patterning on multiple length scales down to the sub-100 nm level is required. The relevant distances and length scales of ligand clustering in multivalent recognition and those in protein clustering in focal adhesion of certain types of cells on the one hand, and the size of biological entities such as bacteria or cells on the other hand, span an enormous range.