Magnetically Triggered Reversible Controlled Drug Delivery from Microfabricated Polymeric Multireservoir Devices

摘要

This report describes a simple approach to generate biodegradable polymeric multireservoir devices that allow the magnetically reversible controlled pulsatile release of DNA and vitamin B2 to be carried out via incorporation of magnetic particles as switch carriers. Controlled drug release is essential to accomplish optimum therapeutic effect, which remains one of the great challenges in medicine. Oral delivery is one of the most preferred modes of drug administration; however, the poor oral bioavail-ability of most therapeutic macromolecules requires the development of alternative methods for drug delivery. Over the past decades, various types of carriers have been developed to achieve controlled drug delivery, including microspheres, microcap-sules, hydrogels, microfabricated drug-delivery devices, etc. The demand for efficient drug delivery and administration requires the ability of in situ controlled drug delivery.