Microstructured Tungsten Oxide: A Generic Desorption/lonization Substrate for Mass Spectrometry

摘要

The development of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) by Hillenkamp and Karas for characterizing molecules was a significant breakthrough that build upon the 2002 Nobel-prize winning studies of Tanaka on soft desorption ionization methods for mass spectrometric analyses.Typically, MALDI-MS involves using the output of an ultraviolet (UV) or infrared (IR) laser to excite a solid solution containing a small light-absorbing organic molecule (matrix) which has been co-crystallized with a non-absorbing analyte of interest.