Controlled Hierarchical Architecture in Surface-initiated Zwitterionic Polymer Brushes with Structurally Regulated Functionalities

摘要

Surface chemistries for biosensors, implantable medical devices targeted drug/gene delivery carriers, tissue scaf-folds, and targeted molecular imaging probes in complex media remain a great challenge due to high nonspecific adsorp-tion and low binding capacity of molecular recognition ele-ments. Currently, few materials have been developed to reduce nonspecific protein adsorption, including poly(ethylene glycol) (PEG), mannitol tetraglyme, and zwitterionic polymers.