Non-Invasive Synergistic Treatment of Brain Tumors by Targeted Chemotherapeutic Delivery and Amplified Focused Ultrasound-Hyperthermia Using Magnetic Nanographene Oxide

摘要

Brain tumors have a low incidence but high lethality compared to other cancers. Glioblastoma multiforme (GBM) is the most common primary brain tumor and is highly malignant, and most tumors recur locally within 2 cm of the original lesion. The blood-brain barrier (BBB) prevents diffusion of toxic foreign substances into the brain parenchyma but also presents an almost impenetrable barrier to most chemotherapeutics. Although ≈10-20% of an administered chemotherapeutic agent such as Carmustine (BCNU) and temozolomide can cross the BBB, progression-free survival is typically less than six months.