Engineered Multifunctional Nanomedicine for Simultaneous Stereotactic Chemotherapy and Inhibited Osteolysis in an Orthotopic Model of Bone Metastasis

Li Chunyan; Zhang Yejun; Chen Guangcun; Hu Feng; Zhao Kui; Wang Qiangbin

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Engineered Multifunctional Nanomedicine for Simultaneous Stereotactic Chemotherapy and Inhibited Osteolysis in an Orthotopic Model of Bone Metastasis

机译：工程化多功能纳米药物在骨转移原位模型中同时进行立体定向化学疗法和抑制溶骨作用

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A novel multifunctional Ag2S quantum dot (QD)-based nanomedicine of alendronate (Ald)/doxorubicin (DOX)@Ag2S is developed for highly effective bone tumor therapy in an orthotopic model. The bone-targeting and osteolysis inhibition of Ald and the chemotherapeutic effect of DOX on the bone tumor are in situ visualized by Ag2S QDs with emission in the second near-infrared window.

机译：阿仑膦酸盐（Ald）/阿霉素（DOX）@ Ag2S的新型多功能基于Ag2S量子点（QD）的纳米药物被开发用于原位模型中的高效骨肿瘤治疗。 Ag2S QDs在第二个近红外窗口中发射光，就地观察到Ald的骨靶向和溶骨抑制作用以及DOX对骨肿瘤的化学治疗效果。

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《Advanced Materials》 |2017年第13期|1605754.1-1605754.7|共7页
作者
Li Chunyan; Zhang Yejun; Chen Guangcun; Hu Feng; Zhao Kui; Wang Qiangbin;
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Chinese Acad Sci, CAS Key Lab Nanobio Interface, Div Nanobiomed, Suzhou 215123, Peoples R China|Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, CAS Ctr Excellence Brain Sci, i Lab, Suzhou 215123, Peoples R China;

Chinese Acad Sci, CAS Key Lab Nanobio Interface, Div Nanobiomed, Suzhou 215123, Peoples R China|Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, CAS Ctr Excellence Brain Sci, i Lab, Suzhou 215123, Peoples R China;

Chinese Acad Sci, CAS Key Lab Nanobio Interface, Div Nanobiomed, Suzhou 215123, Peoples R China|Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, CAS Ctr Excellence Brain Sci, i Lab, Suzhou 215123, Peoples R China;

Chinese Acad Sci, CAS Key Lab Nanobio Interface, Div Nanobiomed, Suzhou 215123, Peoples R China|Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, CAS Ctr Excellence Brain Sci, i Lab, Suzhou 215123, Peoples R China;

Soochow Univ, Affiliated Hosp 2, 1055 Sanxiang Rd, Suzhou 215004, Peoples R China;

Chinese Acad Sci, CAS Key Lab Nanobio Interface, Div Nanobiomed, Suzhou 215123, Peoples R China|Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, CAS Ctr Excellence Brain Sci, i Lab, Suzhou 215123, Peoples R China;

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Engineered Multifunctional Nanomedicine for Simultaneous Stereotactic Chemotherapy and Inhibited Osteolysis in an Orthotopic Model of Bone Metastasis

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