Dealing with the Foreign-Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

摘要

Foreign-body response caused by implanted biomaterials seriously impedes the function of implants and is a major obstacle to the development of implantable biomaterials and medical devices. Recent advances in implantable biomaterials and medical devices have provided strategies to resist the foreign-body response. In this review, the mechanism of the foreign-body response and conventional strategies to mitigate foreign-body response is briefly introduced. Then, three types of promising foreign-body response resisting materials are focused and the advantages, characteristics, and applications of each material are discussed. Finally, prospects are put forward for future development of foreign-body response resisting materials and current challenges that require in-depth study.