Relevance between striatal expression of Fos, proenkephalin mRNA, prodynorphin mRNA, and rotation induced by l-stepholi- dine in 6-hydroxydopamine-lesioned rats

摘要

(1) Following repeated SPD treatment, the rotation was kept On high activity in the 6-OHDA-lesioned rats.(2)SPD Significantly elicited Fos expression in both sides of stria- Tum, particularly in the denervated one. In the -OHDA-le- Sioned rats, the rotation induced by SPD was kept on a High activity, which was in pace with the inducement of Fos expression and the reduction of expression of PENK mRNA in the denervated triatum. But then the lesion and SPD treatment had no remarkable effect on the ex- pressoin of PDYN mRAN.