Electrospun Zein/PCL Fibrous Matrices Release Tetracycline in a Controlled Manner Killing Staphylococcus aureus Both in Biofilms and Ex Vivo on Pig Skin and are Compatible with Human Skin Cells

摘要

PurposeTo investigate the destruction of clinically-relevant bacteria within biofilms via the sustained release of the antibiotic tetracycline from zein-based electrospun polymeric fibrous matrices and to demonstrate the compatibility of such wound dressing matrices with human skin cells.