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Original article: Treatment efficacy and methotrexate-related toxicity in patients with rheumatoid arthritis receiving methotrexate in combination with adalimumab

机译：原始文章：甲氨蝶呤联合阿达木单抗治疗类风湿关节炎的疗效和与甲氨蝶呤相关的毒性

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摘要

BackgroundTreatment of rheumatoid arthritis (RA) with a combination of methotrexate (MTX)+adalimumab (ADA) is more effective than ADA monotherapy. We assessed the toxicity of different doses of MTX and treatment efficacy of ADA+MTX in two trials.

机译：背景甲氨蝶呤（MTX）+阿达木单抗（ADA）联合治疗类风湿关节炎（RA）比ADA单药治疗更有效。在两项试验中，我们评估了不同剂量的MTX的毒性和ADA + MTX的治疗效果。

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期刊名称 RMD Open
作者
Gerd R Burmester; Gurjit S Kaeley; Arthur F Kavanaugh; Cem Gabay; Daryl K MacCarter; Peter Nash; Tsutomu Takeuchi; Sandra L Goss; Ramona Rodila; Kun Chen; Hartmut Kupper; Jasmina Kalabic;
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年(卷),期 2012(3),2
年度 2012
页码 e000465
总页数 9
原文格式 PDF
正文语种
中图分类
关键词
adalimumab, methotrexate, rheumatoid arthritis, combination treatment, toxicity, efficacy;

机译：阿达木单抗;甲氨蝶呤;类风湿关节炎;联合治疗;毒性;疗效;

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专利

1. Treatment efficacy and methotrexate-related toxicity in patients with rheumatoid arthritis receiving methotrexate in combination with adalimumab [J] . Hartmut Kupper, Arthur F Kavanaugh, Gurjit S Kaeley, RMD Open . 2017,第2期

机译：甲氨蝶呤联合阿达木单抗治疗类风湿关节炎的疗效和甲氨蝶呤相关毒性
2. Original article: Cotreatment with methotrexate in routine care patients with rheumatoid arthritis receiving biological treatment yields better outcomes over time [J] . Niels W. Boone, Alexandre Sepriano, Paul-Hugo van der Kuy, RMD Open . 2019,第1期

机译：原始文章：在接受生物治疗的类风湿性关节炎的常规护理患者中，甲氨蝶呤的联合治疗可带来更好的治疗效果
3. Comparative efficacy and safety of biosimilar adalimumab and originator adalimumab in combination with methotrexate in patients with active rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials [J] . Bae Sang-Cheol, Lee Young Ho Clinical rheumatology . 2018,第5期

机译：生物仿生毒率和发起剂Adalimalab与活性类风湿性关节炎患者结合甲氨蝶呤的比较疗效和安全性：随机对照试验的贝叶斯网络荟萃分析
4. Antiresorptive effect of denosumab in the treatment of osteoporosis in patients with rheumatoid arthritis [C] . M. A. Korolev, N. E. Banshchikova, E. A. Letjagina, 2017 International Multi-Conference on Engineering, Computer and Information Sciences . 2017

机译：地诺单抗对类风湿关节炎骨质疏松症的抗吸收作用
5. Development and characterization of methotrexate loaded poly(L-lactic acid) microspheres for the treatment of rheumatoid arthritis. [D] . Liang, Sanching Linda. 2006

机译：甲氨蝶呤负载聚（L-乳酸）微球的开发和表征，用于治疗类风湿关节炎。
6. Original article: Adalimumab discontinuation in patients with early rheumatoid arthritis who were initially treated with methotrexate alone or in combination with adalimumab: 1 year outcomes of the HOPEFUL-2 study [O] . Yoshiya Tanaka, Hisashi Yamanaka, Naoki Ishiguro, 2016

机译：原始文章：早期类风湿关节炎患者的阿达木单抗停药最初接受甲氨蝶呤单独治疗或与阿达木单抗联合治疗：HOPEFUL-2研究的结局为1年
7. SLC19A1, SLC46A1 and SLCO1B1 Polymorphisms as Predictors of Methotrexate-Related Toxicity in Portuguese Rheumatoid Arthritis Patients [O] . Aurea Lima, Miguel Bernardes, Rita Azevedo, 2014

机译：SLC19A1，SLC46A1和SLCO1B1多态性作为葡萄牙类风湿性关节炎患者甲氨蝶呤相关毒性的预测因子

Original article: Treatment efficacy and methotrexate-related toxicity in patients with rheumatoid arthritis receiving methotrexate in combination with adalimumab

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