614. Modeling Changes in Gastrointestinal and Respiratory Tract Bacterial Community Diversity Attributable to Common Antibiotic Exposures During Long-Term Acute Care

摘要

BackgroundReduced gastrointestinal tract bacterial community diversity has been associated with increased risk for healthcare-associated infections, including Clostridium difficile infection. We sought to develop a model for concomitant change in bacterial community diversity at gastrointestinal and respiratory tract sites, drawing upon a recently completed cohort study of 92 subjects recruited from a long-term acute care hospital (LTACH) for dense longitudinal oral, endotracheal aspirate (ET), and stool specimen collection.