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Sex-specific clinicopathological significance of novel (Frizzled-7) and established (MGMT, IDH1) biomarkers in glioblastoma

机译：胶质母细胞瘤中新型（Frizzled-7）和已建立（MGMT，IDH1）生物标志物的性别特异性临床病理意义

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摘要

BackgroundThe Wnt receptor Frizzled-7 (FZD7) promotes tumor progression and can be currently targeted by monoclonal antibody therapy. Here, we determined the prognostic value of FZD7 for the overall survival of glioblastoma (GBM) patients, both as individual marker and taken in combination with the previously-described markers MGMT and IDH1. Additionally, we tested whether these markers (alone or in combination) exhibited sex-specific differences.

机译：背景Wnt受体Frizzled-7（FZD7）促进肿瘤进展，目前可通过单克隆抗体疗法靶向。在这里，我们确定了FZD7对胶质母细胞瘤（GBM）患者总体生存的预后价值，既作为单独的标志物，又与前述标志物MGMT和IDH1结合使用。此外，我们测试了这些标记（单独或组合使用）是否表现出性别特异性差异。

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期刊名称 Oncotarget
作者
Salveena Schiffgens; Ludwig Wilkens; Alba A. Brandes; Tatiana Meier; Enrico Franceschi; Mario Ermani; Christian Hartmann; Ibrahim Erol Sandalcioglu; Claudia A. Dumitru;
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作者单位

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年(卷),期 1967(7),34
年度 1967
页码 55169–55180
总页数 12
原文格式 PDF
正文语种
中图分类肿瘤学;细胞生物学;
关键词
Frizzled-7, MGMT, IDH1, sex-specific biomarkers, glioblastoma;

机译：Frizzled-7;MGMT;IDH1;性别特异性生物标志物;胶质母细胞瘤;

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专利

1. The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone [J] . Remco J. Molenaar, Dagmar Verbaan, Simona Lamba, Neuro-Oncology . 2014,第9期

机译：IDH1突变和MGMT甲基化状态的组合比单独使用IDH1或MGMT预测胶质母细胞瘤的存活更好
2. IDH1 mutations is prognostic marker for primary glioblastoma multiforme but MGMT hypermethylation is not prognostic for primary glioblastoma multiforme [J] . Kalkan Rasime, Atli Emine Ikbal, Ozdemir Muhsin, Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function . 2015,第1期

机译：IDH1突变是初级胶质母细胞瘤的预后标志物，但MGMT高甲基化不是对原发性胶质母细胞瘤的预后
3. IDH1 mutations is prognostic marker for primary glioblastoma multiforme but MGMT hypermethylation is not prognostic for primary glioblastoma multiforme. [J] . Rasime Kalkan, Emine ?kbal Atli, Muhsin Ozdemir, Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function . 2014,第1期

机译：IDH1突变是多形原发性胶质母细胞瘤的预后标志物，但MGMT甲基化水平对多形原发性胶质母细胞瘤没有预后性。
4. Multi-label Inductive Matrix Completion for Joint MGMT and IDH1 Status Prediction for Glioma Patients [C] . Lei Chen, Han Zhang, Kim-Han Thung, International conference on medical imaging computing and computer-assisted intervention . 2017

机译：胶质瘤患者的MGMT和IDH1联合状态预测的多标签感应矩阵完成
5. Combining biomarkers and clinicopathologic factors for prediction of response to adjuvant chemotherapy for breast cancer: Cox model and Support Vector Machine (SVM) methods. [D] . Liu, Xudong. 2010

机译：结合生物标志物和临床病理因素预测乳腺癌对辅助化疗的反应：Cox模型和支持向量机（SVM）方法。
6. The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone [O] . Remco J. Molenaar, Dagmar Verbaan, Simona Lamba, 2014

机译：IDH1突变和MGMT甲基化状态的组合比单独使用IDH1或MGMT预测胶质母细胞瘤的存活更好
7. The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone [O] . Remco J. Molenaar, Dagmar Verbaan, Simona Lamba, 2014

机译：IDH1突变和MgMT甲基化状态的组合预测胶质母细胞瘤的存活优于单独的IDH1或MgMT

Sex-specific clinicopathological significance of novel (Frizzled-7) and established (MGMT, IDH1) biomarkers in glioblastoma

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