Parsing Physiological Functions of Erythropoietin One Domain at a Time

摘要

A domain of erythropoietin (EPO), separate from the domain involved in red blood cell development, has been identified. This region of EPO has anti-inflammatory and neuroprotective effects. Use of a peptide sequence from this region provides the potential for an effective therapeutic without effects on erythropoiesis.Electronic supplementary materialThe online version of this article (doi:10.1007/s13311-015-0384-4) contains supplementary material, which is available to authorized users.