Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis

机译：三阴性乳腺癌取决于鞘氨醇激酶1（SphK1）/鞘氨醇-1-磷酸（S1P）/鞘氨醇1-磷酸受体3（S1PR3）/ Notch信号转移。

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BackgroundTriple negative breast cancer (TNBC) has a more aggressive recurrence. Previous reports have demonstrated that sphingosine kinase 1 (SphK1) is a crucial regulator of breast cancer progression. However, the correlation of SphK1 with clinical prognosis has been poorly investigated. Thus, we aimed to elaborate the role of SphK1 in TNBC metastasis.

机译：背景三阴性乳腺癌（TNBC）的复发率更高。以前的报告表明，鞘氨醇激酶1（SphK1）是乳腺癌进展的关键调节剂。然而，SphK1与临床预后的相关性研究很少。因此，我们旨在阐明SphK1在TNBC转移中的作用。

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期刊名称 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
作者
Shushu Wang; Yueyang Liang; Wenxiao Chang; Baoquan Hu; Yi Zhang;
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作者单位

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年(卷),期 1923(24),
年度 1923
页码 1912–1923
总页数 12
原文格式 PDF
正文语种
中图分类
关键词
Neoplasm Metastasis, Receptors, Lysosphingolipid, Triple Negative Breast Neoplasms;

机译：肿瘤转移;受体;鞘脂脂;三阴性乳腺肿瘤;

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专利

1. O-56 High expression of sphingosine 1-phosphate receptors, S1P"1 and S1P"3, sphingosine kinase 1 and ERK-1/2 is associated with development of tamoxifen resistance in ER positive breast cancer patients [J] . Carol Watson, Jaclyn S. Long, Clare Orange, European Journal of Cancer Supplements . 2010,第6期

机译：O-56鞘氨醇1-磷酸受体，S1P“ 1和S1P” 3，鞘氨醇激酶1和ERK-1 / 2的高表达与ER阳性乳腺癌患者中他莫昔芬耐药性的发展有关
2. Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4 [J] . Jan Ohotski, Hugh Rosen, Robert Bittman, Cellular Signalling . 2014,第5期

机译：鞘氨醇激酶2阻止鞘氨醇1-磷酸受体2和酪氨酸416磷酸化的c-Src的核易位并增加雌激素受体阴性MDA-MB-231乳腺癌细胞的生长：鞘氨醇1-磷酸受体4的作用
3. High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. [J] . Watson C, Long JS, Orange C, American Journal of Pathology: Official Publication of the American Association of Pathologists . 2010,第5期

机译：鞘氨醇1-磷酸受体，S1P1和S1P3，鞘氨醇激酶1和细胞外信号调节激酶-1/2的高表达与雌激素受体阳性乳腺癌患者中他莫昔芬耐药性的发展有关。
4. Predicting Triple-Negative Breast Cancer and Axillary Lymph Node Metastasis Using Diagnostic MRI [C] . Jeff Wang, Fumi Kato, Kohsuke Kudo, International workshop on breast imaging . 2014

机译：使用诊断性MRI预测三阴性乳腺癌和腋窝淋巴结转移
5. Sphingosine Kinase-2/Sphingosine 1-Phosphate Signaling Regulates Telomerase in Lung Cancer. [D] . Panneer Selvam, Shanmugam. 2013

机译：Sphingosine Kinase-2 / Sphingosine 1-磷酸信号调节肺癌中的端粒酶。
6. High Expression of Sphingosine 1-Phosphate Receptors S1P1 and S1P3 Sphingosine Kinase 1 and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients [O] . Carol Watson, Jaclyn S. Long, Clare Orange, 2010

机译：鞘氨醇1-磷酸受体S1P1和S1P3鞘氨醇激酶1和细胞外信号调节激酶-1/2的高表达与雌激素受体阳性乳腺癌患者他莫昔芬耐药性的发展有关。
7. Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth : the role of sphingosine 1-phosphate receptor-4 [O] . Ohotski, Jan, Rosen, Hugh, Bittman, Robert, 2014

机译：鞘氨醇激酶2阻止鞘氨醇1-磷酸受体2和酪氨酸416磷酸化c-Src的核易位并增加雌激素受体阴性MDA-MB-231乳腺癌细胞的生长：鞘氨醇1-磷酸受体4的作用

Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis

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