首页> 美国卫生研究院文献>Journal of Cerebral Blood Flow Metabolism >Age-associated physiological and pathological changes at the blood–brain barrier: A review
【2h】

Age-associated physiological and pathological changes at the blood–brain barrier: A review

机译:血脑屏障中与年龄相关的生理和病理变化:综​​述

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

The age-associated decline of the neurological and cognitive functions becomes more and more serious challenge for the developed countries with the increasing number of aged populations. The morphological and biochemical changes in the aging brain are the subjects of many extended research projects worldwide for a long time. However, the crucial role of the blood–brain barrier (BBB) impairment and disruption in the pathological processes in age-associated neurodegenerative disorders received special attention just for a few years. This article gives an overview on the major elements of the blood–brain barrier and its supporting mechanisms and also on their alterations during development, physiological aging process and age-associated neurodegenerative disorders (Alzheimer's disease, multiple sclerosis, Parkinson's disease, pharmacoresistant epilepsy). Besides the morphological alterations of the cellular elements (endothelial cells, astrocytes, pericytes, microglia, neuronal elements) of the BBB and neurovascular unit, the changes of the barrier at molecular level (tight junction proteins, adheres junction proteins, membrane transporters, basal lamina, extracellular matrix) are also summarized. The recognition of new players and initiators of the process of neurodegeneration at the level of the BBB may offer new avenues for novel therapeutic approaches for the treatment of numerous chronic neurodegenerative disorders currently without effective medication.
机译:随着年龄增长的人口数量的增加,与年龄相关的神经和认知功能下降已成为发达国家越来越严峻的挑战。长期以来,衰老的大脑中的形态和生化变化是许多扩展研究项目的主题。然而,与年龄相关的神经退行性疾病的病理过程中血脑屏障(BBB)损伤和破坏的关键作用仅受到了几年的关注。本文概述了血脑屏障的主要成分及其支持机制,以及它们在发育,生理性衰老过程以及与年龄相关的神经退行性疾病(阿尔茨海默氏病,多发性硬化症,帕金森氏病,药物耐药性癫痫)中的变化。除了血脑屏障和神经血管单元的细胞成分(内皮细胞,星形胶质细胞,周细胞,小胶质细胞,神经元)的形态改变外,在分子水平(紧密连接蛋白,粘附连接蛋白,膜转运蛋白,基底层)的屏障变化(细胞外基质)。在BBB水平上对神经退行性过程的新参与者和始发者的认可可能为新颖的治疗方法提供新途径,该方法可用于治疗许多目前尚无有效药物治疗的慢性神经退行性疾病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号