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The Role of Estrogen Receptor β (ERβ) in the Establishment of Hierarchical Social Relationships in Male Mice

机译:雌激素受体β(ERβ)在建立雄性小鼠等级社会关系中的作用

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摘要

Acquisition of social dominance is important for social species including mice, for preferential access to foods and mates. Male mice establish social rank through agonistic behaviors, which are regulated by gonadal steroid hormone, testosterone, as its original form and aromatized form. It is well known that estrogen receptors (ERs), particularly ER α (ERα), mediate effects of aromatized testosterone, i.e., 17β-estradiol, but precise role played by ER β (ERβ) is still unclear. In the present study, we investigated effects of ERβ gene disruption on social rank establishment in male mice. Adult male ERβ knockout (βERKO) mice and their wild type (WT) littermates were paired based on genotype- and weight-matched manner and tested against each other repeatedly during 7 days experimental period. They underwent 4 trials of social interaction test in neutral cage (homogeneous set test) every other day. Along repeated trials, WT but not βERKO pairs showed a gradual increase of agonistic behaviors including aggression and tail rattling, and a gradual decrease of latency to social rank determination in tube test conducted after each trial of the social interaction test. Analysis of behavioral transition further suggested that WT winners in the tube test showed one-sided aggression during social interaction test suggesting WT pairs went through a process of social rank establishment. On the other hand, a dominant-subordinate relationship in βERKO pairs was not as apparent as that in WT pairs. Moreover, βERKO mice showed lower levels of aggressive behavior than WT mice in social interaction tests. These findings collectively suggest that ERβ may play a significant role in the establishment and maintenance of hierarchical social relationships among male mice.
机译:获得社会支配地位对于包括老鼠在内的社会物种而言,对于优先获得食物和伴侣至关重要。雄性小鼠通过激动行为来建立社会地位,这种行为受性腺类固醇激素,睾丸激素作为其原始形式和芳香化形式的调节。众所周知,雌激素受体(ERs),特别是ERα(ERα)介导芳香化睾丸激素即17β-雌二醇的作用,但是ERβ(ERβ)所起的确切作用仍不清楚。在本研究中,我们调查了ERβ基因破坏对雄性小鼠社交等级建立的影响。根据基因型和体重匹配的方式将成年雄性ERβ基因敲除(βERKO)小鼠及其野生型(WT)同窝配对,并在7天的实验期内反复进行相互测试。他们每隔一天在中性的笼子里进行4项社交互动测试(均质性测试)。经过反复试验,在每次社交互动测试后进行的试管测试中,WT(而非βERKO)对显示出包括攻击性和尾巴嘎嘎声在内的激动行为逐渐增加,并且对社交等级确定的潜伏性逐渐降低。行为过渡的分析进一步表明,WT测试的优胜者在社交互动测试中表现出单方面的攻击性,这表明WT对经历了社会等级的建立过程。另一方面,βERKO对中的主从关系并不像WT对中那样明显。此外,在社交互动测试中,βERKO小鼠的攻击行为水平低于WT小鼠。这些发现共同表明,ERβ可能在雄性小鼠之间建立和维持等级社会关系中起重要作用。

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