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Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate

机译：使用磁共振波谱和超极化丙酮酸测定体内对大鼠肿瘤缺氧的急性代谢反应

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PurposeTo estimate the rate constant for pyruvate to lactate conversion in tumours in response to a hypoxic challenge, using hyperpolarised ¹³C1-pyruvate and magnetic resonance spectroscopy.

机译：目的利用超极化的^{13 C1-丙酮酸盐和磁共振波谱技术评估低氧激发下丙酮酸转化为乳酸的速率常数。}

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期刊名称 Elsevier Sponsored Documents
作者
Joanne E. Bluff; Steven Reynolds; Stephen Metcalf; Tooba Alizadeh; Samira M. Kazan; Adriana Bucur; Emily G. Wholey; Becky A.S. Bibby; Leigh Williams; Martyn N. Paley; Gillian M. Tozer;
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年(卷),期 -1(116),3
年度 -1
页码 392–399
总页数 8
原文格式 PDF
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关键词
Tumour oxygenation Magnetic resonance spectroscopy Dynamic nuclear polarisation Pyruvate metabolism;

机译：肿瘤氧合;磁共振波谱;动态核极化;丙酮酸代谢;

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专利

1. Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate [J] . Bluff Joanne E., Reynolds Steven, Metcalf Stephen, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2015,第3期

机译：使用磁共振波谱和超极化丙酮酸测定体内对大鼠肿瘤缺氧的急性代谢反应
2. In vivo measurement of the hypoxia marker EF5 in Shionogi tumours using (19)F magnetic resonance spectroscopy. [J] . Hoff MN, Yapp DT, Yung AC, International Journal of Radiation Biology: Covering the Physical, Chemical, Biological, and Medical Effects of Ionizing and Non-ionizing Radiations . 2008,第3期

机译：使用（19）F磁共振波谱对Shionogi肿瘤中的缺氧标记EF5进行体内测量。
3. C-13 Magnetic Resonance Spectroscopy Measurements with Hyperpolarized [1-C-13] Pyruvate Can Be Used to Detect the Expression of Transgenic Pyruvate Decarboxylase Activity In Vivo [J] . Dzien Piotr, Tee Sui-Seng, Kettunen Mikko I., Magnetic resonance in medicine: official journal of the Society of Magnetic Resonance in Medicine . 2016,第2期

机译：超极化[1-C-13]丙酮酸的C-13磁共振光谱测量可用于检测转基因丙酮酸脱羧酶活性的表达
4. A Met a-Classifier for Detecting Prostate Cancer by Quantitative Integration of In Vivo Magnetic Resonance Spectroscopy and Magnetic Resonance Imaging [C] . Satish Viswanath, Pallavi Tiwari, Mark Rosen, Conference on Medical Imaging 2008: Computer-Aided Diagnosis; 20080219-21; San Diego,CA(US) . 2008

机译：一种通过体内磁共振波谱和磁共振成像定量积分检测前列腺癌的Met分类器
5. Laser-polarized xenon-129 magnetic resonance spectroscopy and imaging. The development of a method for in vivo perfusion measurement. [D] . Rosen, Matthew Scot. 2001

机译：激光偏振氙129磁共振波谱和成像。体内灌注测量方法的发展。
6. 13C magnetic resonance spectroscopy measurements with hyperpolarized 1‐13C pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo [O] . Piotr Dzien, Sui‐Seng Tee, Mikko I. Kettunen, -1

机译：超极化1-13C丙酮酸的13C磁共振波谱测量可用于检测体内转基因丙酮酸脱羧酶活性的表达
7. Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate [O] . Bluff, J.E., Reynolds, S., Metcalf, S., 2015

机译：使用磁共振波谱法和超极化丙酮酸测量体内大鼠肿瘤对缺氧的急性代谢反应

Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate

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