Amelioration of non-motor dysfunctions after transplantation of human dopamine neurons in a model of Parkinsons disease

摘要

BackgroundPatients suffering from Parkinson's disease (PD) display cognitive and neuropsychiatric dysfunctions, especially with disease progression. Although these impairments have been reported to impact more heavily upon a patient's quality of life than any motor dysfunctions, there are currently no interventions capable of adequately targeting these non-motor deficits.